ABSTRACT
The effects of captopril (2 mg/kg i.p.) and cadmium (1 mg/kg i.p.) at three different time points (30, 60, 180 min) on serum angiotensin converting enzyme (ACE), blood pressure (BP) and heart rate (HR) were examined in male Sprague-Dawley rats. Captopril produced significant inhibition of ACE at 60 and 120 minutes, while maximum fall of BP (15 mm Hg) was obtained at 30 minutes post-test drug treatment. Heart rate at the three different time intervals did not change significantly. ACE levels in the serum were significantly reduced at different time intervals (30, 60, 120 min) in the cadmium-treated group as compared with controls (p < 0.05). Cadmium increased the blood pressure and heart rate of rats. The results indicate that while both cadmium and captopril produce different effects on blood pressure and heart rate, both of these also inhibit the serum ACE in rats.
Subject(s)
Angiotensin-Converting Enzyme Inhibitors/pharmacology , Animals , Blood Pressure/drug effects , Cadmium/pharmacology , Captopril/pharmacology , Heart Rate/drug effects , Male , Peptidyl-Dipeptidase A/blood , Rats , Rats, Sprague-Dawley , Time FactorsABSTRACT
The effect of cadmium acetate (0.1, 0.3, 1.0 mg/kg, i.v.) alone and following verapamil (2.5 mg/kg, i.v.), in male Sprague Dawley (S-D) rats on blood pressure (BP) and heart rate (HR) were examined. Cadmium acetate produced dose dependent effect on BP and HR. Cadmium injected intravenously in different doses produced initial transient fall followed by a persistent rise in blood pressure and heart rate. Verapamil pretreatment attenuated the BP and HR responses in rats. These findings indicate that two blockers of calcium channels produce different effects on BP and HR in rats.